This page follows this one : How to reduce the QHY5's noise (step 1)
Choose the right software ;-)
Another way to reduce the noise is to use a software filter. Qastrocam-g2 (link) now offers a noise reduction filter for the QHY5. This fitler uses the sensor's black pixels on each line to adjuste the black levels on these lines. Have look on these two samples :
One second dark frame at full gain, without filter...
... and with the filter :
One second light frame at full gain, without filter...
... and with the filter :
Sure, we loose some dynamic, but the SNR is much better ;-)